Minnesota at Detroit 1:10 PM ET
A player with a famous last name will likely make his major league debut when the Detroit Tigers host the Minnesota Twins in a doubleheader on Tuesday.
Kansas City at Cleveland 6:10 PM ET
The Kansas City Royals, heading into the middle game of a three-game series against the host Cleveland Guardians on Tuesday, really could use their first complete game of the season, because their bullpen is struggling.
San Francisco at Philadelphia 6:45 PM ET
The San Francisco Giants will look for their third consecutive victory when they play host to the Philadelphia Phillies in the middle game of a three-game series on Tuesday.
Seattle at Baltimore 7:05 PM ET
Though the Baltimore Orioles are in last place in the American League East, their recent play suggests they are getting better as they return home to face the Seattle Mariners in the opener of a three-game series on Tuesday.
LA Angels at NY Yankees 7:05 PM ET
Shohei Ohtani and Mike Trout are in their fifth season as teammates, but injuries have prevented the duo from being available at the same time for games at Yankee Stadium.
Chi. White Sox at Toronto 7:07 PM ET
The Chicago White will be without shortstop Tim Anderson for their six-game road trip that opens Tuesday night against the Toronto Blue Jays.
Cincinnati at Boston 7:10 PM ET
Two unfamiliar opponents will begin a two-game series on Tuesday night as the Boston Red Sox host the Cincinnati Reds.
Washington at NY Mets 7:10 PM ET
A reporter asked New York Mets manager Buck Showalter after his team's 13-5 victory over the Washington Nationals on Monday night if he has allowed himself to enjoy his team's big lead in the National League East. To be fair, the questioner put in the caveat that it is early.
San Diego at St. Louis 7:45 PM ET
San Diego left-hander Blake Snell will test his rebuilt stamina when the Padres oppose the host St. Louis Cardinals on Tuesday.
Milwaukee at Chi. Cubs 8:05 PM ET
With the Milwaukee Brewers' pitching staff hindered by injuries of late, Eric Lauer likely needs to continue the best early-season run of his career.
Tampa Bay at Texas 8:05 PM ET
When the Texas Rangers signed Martin Perez as a free agent in March, it represented a reunion for the left-hander with the organization.
Miami at Colorado 8:40 PM ET
German Marquez was trending in the right direction when he made the National League All-Star team last season. It was further proof the Colorado Rockies were smart to sign him to an extension in 2019.
Houston at Oakland 9:40 PM ET
The visiting Houston Astros will have a rested bullpen and a surging power attack when they square off against the Oakland Athletics on Tuesday night in the middle game of a three-game American League West series.
Atlanta at Arizona 9:40 PM ET
A pair of pitchers trying to bounce back from below-average starts will oppose each other Tuesday night when the Arizona Diamondbacks face the Atlanta Braves in the second game of a three-game set in Phoenix.
Pittsburgh at LA Dodgers 10:10 PM ET
The Pittsburgh Pirates appear to have cracked the code when it comes to beating the Los Angeles Dodgers and will look for another victory when the teams meet Tuesday night at Los Angeles.