| Player |
|
Status/Updated |
Notes |
| Jimmy Garoppolo
|
QB |
Prob Sun - Calf - 10/21/21 |
Garoppolo missed the last game due to a calf contusion, but it is anticipated that he will be available on Sunday against the Colts. |
| JaMycal Hasty
|
RB |
Prob Sun - Ankle - 10/23/21 |
Hasty has been activated from the Injured Reserve/Designated for Return list after recovering from a high-ankle sprain, and he is likely to suit up for Sunday's clash with the Colts. |
| Marcell Harris
|
LB |
Ques Sun - Thumb - 10/19/21 |
Harris is sidelined while having surgery to repair a broken right thumb, and it is unclear if he will be active for Sunday's clash with the Colts. |
| Maurice Hurst
|
DL |
Out Sun - Calf - 10/22/21 |
Hurst is managing a calf injury, and he will not lace up against the Colts on Sunday. |
| Javon Kinlaw
|
DT |
Out Sun - Knee - 10/22/21 |
Kinlaw is battling a knee injury, and he will not be available against the Colts on Sunday. |
| Trent Williams
|
T |
Out Sun - Ankle - 10/24/21 |
Williams is battling an ankle and elbow injury, and he will not be active for Sunday's showdown with the Colts. |
| Trey Lance
|
QB |
Out Sun - Knee - 10/22/21 |
Lance is battling a left knee sprain, and he will not be active for Sunday's tilt against the Colts. |
| K'Waun Williams
|
CB |
Out indefinitely - Calf - 9/28/21 |
Williams is tending to a calf strain, and a date for his return to action is unclear. |
| Jordan Willis
|
DL |
Elig Week 8 - Suspension - 6/18/21 |
Willis has been suspended for six games due to violating the league's policy on performance-enhancing substances. He is expected to be ready for Week 8 versus the Bears. |
| Justin Skule
|
OL |
out for season - Knee - 6/16/21 |
Skule suffered a torn ACL and will miss the entire season. |
| George Kittle
|
TE |
Out indefinitely - Calf - 10/9/21 |
Kittle has hit the injured reserve list due to a calf injury, and there is no timetable for return. |
| Robbie Gould
|
K |
Out indefinitely - Groin - 10/6/21 |
Gould has been added to the injured reserve list with a groin injury, and a date for his return has yet to be determined. |
| Kevin Givens
|
DL |
Out indefinitely - Ankle - 9/25/21 |
Givens has hit the injured reserve list with a high ankle sprain, and it has yet to be established if he will return to action |
| Dre Greenlaw
|
LB |
Mid Nov - Upper Body - 9/18/21 |
Greenlaw has been placed on the injured reserve list after undergoing core muscle surgery, and he is expected to miss six to eight weeks. |
| Raheem Mostert
|
RB |
I-R - Knee - 9/14/21 |
Mostert has been shuttled to the injured reserve list after undergoing season-ending knee surgery. |
| Jason Verrett
|
CB |
I-R - Knee - 9/14/21 |
Verrett has been entered to the injured reserve list due to a torn ACL in his right knee. |
| Jalen Hurd
|
WR |
Out indefinitely - Knee - 9/11/21 |
Hurd has been shuttled to the injured reserve list due to a knee injury, and he will miss an extended period. |
| Richie James
|
WR |
I-R - Knee - 9/6/21 |
James has been entered on the injured reserve list after clearing waivers due to a knee ailment. |
| Jeff Wilson Jr.
|
RB |
Late Nov - Knee - 10/13/21 |
Wilson Jr. has been added to the IR/PUP List while recovering from a torn meniscus, and he is not expected to return to the lineup until at least the later part of November. |
| Tarvarius Moore
|
DB |
Out indefinitely - Achilles - 8/31/21 |
Moore is on the IR/PUP list with a torn Achilles tendon, and he will miss an undetermined length of time. |
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